Background: Ischemic stroke (IS) is a cerebrovascular disease with high incidence and mortality. White matter repair plays an important role in the long-term recovery of neurological function after cerebral ischemia. Neuroprotective microglial responses can promote white matter repair and protect ischemic brain tissue. The aim of this study was to investigate whether hypoxic post-conditioning (HPC) [...]

Case Presentation: 57-year-old male, with history of recurrent idiopathic hypothermic episodes, HFrEF on carvedilol, T2DM on no medication for 3 months, and stage 4 CKD, presented to the ED for altered mentation. Vitals were unremarkable except for hypothermia (86.4°F). Patient was hypoglycemic (62 mg/dL). WBC count was low (1.26 10^3/uL). Urine WBCs were elevated (31-50/HPF). [...]

Case Presentation: A 79 year old African American female with non-ischemic cardiomyopathy, EF 35-40%, hypertension, chronic kidney disease, hypothyroidism, mild pulmonary hypertension, obesity, and mixed hyperlipidemia, presented with worsening dizziness and bipedal edema for 2 weeks. Patient reported stopping diuretics and carvedilol due to persistent hypotension for several months. Patient noted unintentional weight loss of [...]

Case Presentation: A 40-year-old male with no personal or family psychiatric history; presented to the emergency department displaying flight of ideas, a tangential thought process, grandiose delusions, and insomnia for the 10 days prior to admission. His symptoms began 10 days following an uncomplicated SARS-CoV-2 infection that required no treatment. The patient was a highly [...]

Case Presentation: A 73-year-old man with hypertension, atrial fibrillation, coronary artery disease, heart failure, end stage renal disease on hemodialysis, and hypothyroidism presented with 3 weeks of nausea, vomiting, and inability to tolerate food. He had no fevers, abdominal pain, or diarrhea; symptoms did not improve with dialysis. Vitals were normal, abdominal exam was unremarkable, [...]

Case Presentation: A 67-year-old male presented with progressive bilateral upper extremity weakness, diplopia and neck pain of 1 week duration. Patient noted to have bilateral facial droop, weakness and areflexia of both upper extremities on physical exam. He reported having fevers and bloody diarrhea a few months prior to presentation. Magnetic resonance imaging (MRI) of [...]

Case Presentation: A 73 year-old man presented with 2 weeks of difficulty completing multi-step tasks, e.g., getting into a car. At baseline, he was independent in instrumental activities of daily living. He had no other symptoms; he denied headache, weakness, numbness, vision changes, confusion, fevers, chills or weight loss. His history included non-alcoholic steatohepatitis with [...]

Case Presentation: A 26-year-old male, recently diagnosed with Acute Intermittent Porphyria (AIP), presented with 3 days of sudden onset severe periumbilical pain exacerbated by eating. He reported 20 episodes of non-bloody emesis accompanied by bilateral facial numbness and right-sided chest pain in the 3 days prior to admission, as well as subjective fever, chills, and [...]

Case Presentation: A 48-year-old female with past medical history including obesity, T2DM, and tobacco use presented with right eye swelling, pain, and vision loss. She began noticing a dark spot in her right eye about three months prior, which progressed to a pressure-like sensation. A CTA of head and neck showed cavernous sinus hyperdensity. MRI [...]

Case Presentation: An 80-year-old female with a history significant for breast cancer status post mastectomy with chemo/radiation therapy and phenytoin-induced liver injury in 2013 presented with nine months of weakness, weight loss, and 2-3 month history of confusion, memory loss, and widespread tremors, suspicious for focal status epilepticus. Workup revealed hyponatremia (135 mmol/L) and elevated [...]