Case Presentation: A 59-year-old Caucasian woman with asthma and PsA, treated with monthly guselkumab injections, presented with a one-week history of progressive shortness of breath and generalized weakness. Initial laboratory findings revealed leukocytosis and lactic acidosis, and arterial blood gas (ABG) indicated respiratory acidosis. Chest X-ray showed bilateral ground-glass opacities, and echocardiography revealed preserved ejection [...]