Background: Patients (pts) with congestive heart failure (CHF) are at an increased risk for community-acquired bacterial pneumonia (CABP) [1]. Moreover, CABP itself and macrolide antibiotics, which current guidelines recommend for CABP treatment [2], are both associated with increased risk of cardiac events, including worsening heart failure [3,4]. Lefamulin (LEF) is a first-in-class systemic pleuromutilin antibiotic [...]

Case Presentation: A 73-year-old man with a history of atrial fibrillation on apixaban and panhypopituitarism secondary to resection of a pituitary adenoma in the 1980s presented to our hospital for chest pain. His recent history is notable for recurrent cystitis and Clostridium difficile infections requiring stress-doses of glucocorticoids; his endocrinologist had been attempting to taper [...]