Background: Individuals with autoantibodies against melanoma differentiation-associated protein 5 (MDA-5) are reported to have a significant risk of developing rapidly progressive and fatal interstitial lung disease (ILD) in clinically amyopathic dermatomyositis patients (CADM). Previous cohort studies of dermatomyositis patients who have been systematically evaluated for the presence of anti-MDA5 antibodies and associated clinical features and [...]

Case Presentation: A previously healthy 13-year-old male presented with a chief complaint of lower back pain and rash for the past 3 weeks. Associated symptoms included profuse sweating and 10/10 lower back pain radiating to his legs that had progressed in severity with inability to ambulate. On additional questioning, other symptoms included nausea, vomiting, diffuse [...]

Case Presentation: A 69-year-old male with hypertension, prostate cancer in remission, and recent diagnosis of lymphoma presented after experiencing a fall. Prior workup for abdominal pain, fever, night sweats, and weight loss revealed splenomegaly, anemia, and diffuse lymphadenopathy. Bone marrow biopsy demonstrated malignant lymphoma with prominent follicular helper T-cell component occupying 25-30% of the sampled [...]

Case Presentation: A 23-year-old woman presented with complaints of jaundice, nausea, and epigastric pain for ten days. She had a history of epithelioid hemangiodendothelioma (EHE) of the lungs, diagnosed six months prior to presentation. She had been treated with interferon alpha-2b (a type 1 interferon) for four months, but this was stopped two weeks prior [...]

Case Presentation: A 29 year old woman presented with a generalized tonic clonic seizure and progressively worsening ataxia over the last six months. She also had memory deficits and diplopia. Her past medical history included Li Fraumeni syndrome and an immature ovarian teratoma that was treated with a right oophorectomy and chemotherapy in 2015. Her [...]

Case Presentation: A 17yo female with sickle cell disease (SCD; HbSS genotype) presented with pain crisis and acute chest syndrome. She was treated with appropriate antibiotics (ceftriaxone/cefdinir and azithromycin). During the first few days of her hospitalization, she required 2 pRBC transfusions for down trending hemoglobin (Hb) and low reticulocyte count. On hospital day 11, [...]

Case Presentation: A 15 year-old female with obesity presents to the hospital with vomiting, headache, and decreased responsiveness. Prior to arrival she had about 10 episodes of non-bloody vomiting, after which she had altered consciousness. She denied any diarrhea, dysuria, blood in stool, and vaginal bleeding. She denied bleeding and bruising easily. No recent consumption [...]