Case Presentation: A 57 year old man with a history of heart failure with preserved ejection fraction (HFpEF), chronic kidney disease (CKD) and hypertension presented with two weeks of exertional dyspnea and lower extremity edema, followed by 4-days of progressive tongue swelling. One-month prior, he was initiated on an ACE inhibitor (ACEi) and experienced tongue [...]

Case Presentation: A 46-year-old healthy man presented with bilateral limb swelling, shortness of breath, fatigue, and orthopnea for one week. A transthoracic echocardiogram revealed a decreased ejection fraction (35-40%), severe pulmonary hypertension, diffuse hypokinesis, and significantly increased left ventricular wall thickness. Notably, he had presented with similar symptoms seven months earlier. At that time, he [...]

Case Presentation: A 53-year-old woman with a history of irritable bowel syndrome-diarrhea (IBS-D), chronic pain syndrome and years of nonspecific symptoms including chronic diarrhea and neuropathy, presented with bilateral lower extremity edema. Multiple outpatient visits and studies demonstrated nonspecific autoimmune condition with questionable monoclonal gammopathy of undetermined significance (MGUS) as well as a presumed diagnosis [...]