Background: SGLT-2 inhibitors are one of the emerging drugs in heart failure. Several meta-analyses prove its effect in reducing the composite outcome of cardiovascular death/hospitalization for heart failure but it is unknown if they contain all the primary studies hence a need for a pooled analysis Methods: We performed an umbrella analysis and used the [...]

Background: Data on epidemiology of cardiovascular diseases (CVD) in patients with autosomal dominant polycystic kidney disease (ADPKD) are limited. In this study, we assess the prevalence of CVD in patients with ADPKD and evaluate the association between these two entities. Methods: Using the national inpatient sample database, we identified 71,531 hospitalizations among adults aged ≥18 [...]

Background: Transcatheter tricuspid valve procedures (TTVP) are used to manage tricuspid regurgitation, however these procedures are less common than other transcatheter valve procedures. Limited literature on TTVP exists, especially with regards to predictors of major outcomes. Atrial fibrillation (afib) is associated with increased mortality, stroke, cardiogenic shock, need for permanent pacemaker, AKI, major bleeding in [...]

Background: The role of aspirin in primary prevention of cardiovascular events remains controversial, Especially in diabetic patients. We have conducted a meta-analysis of all randomized controlled trials (RCTs) to evaluate the efficacy and safety of aspirin for primary prevention in diabetic patients. Methods: Literature search of Pubmed, MEDLINE, Cochrane Library and Clinicaltrials.gov for related RCTs [...]

Background: Retinal vein occlusion (RVO) has been associated with incident cardiovascular events and mortality in observational studies, but the results have not been consistent. In this systematic review and meta-analysis, we investigate the association of baseline RVO with subsequent development of cardiovascular events and mortality. Methods: Eligible English-language peer-viewed cohort studies in PUBMED and EMBASE [...]

Background: Antipsychotics are frequently used in the hospital setting for managing both acute and chronic psychiatric disorders. However, antipsychotics have been associated with higher rates of mortality due to their cardiovascular risk factors, such as QT prolongation. This study aimed to determine the association between cumulative dose of antipsychotics (first and second-generation) and QT prolongation, [...]

Background: Education is one of the determinants of health as described by the WHO, and it is one of the primary determinants of Socio-Economic Class (SEC), a higher level of education is associated with a higher level of SEC. Few researchers have addressed the link between the level of education and cardiovascular disease. However, there [...]

Background: Clinical practice guidelines (CPG) are a constructive response to the clinical situations providing systematically developed statements that include recommendations intended to optimize patient care. Despite their value, inadequate dissemination and implementation of the CPGs derail quality improvements in patient care. Traditionally, static documents (PDF, HTML pages) have been used to deliver CPGs incorporated into [...]

Background: Hypertension is a significant risk factor for cardiovascular disease. According to the Centers for Disease Control and Prevention (CDC) half of all United States citizens with hypertension (HTN) do not have their blood pressure under control. As such, HTN remains a large public health challenge, especially in patients with other comorbidities such as diabetes [...]

Background: Guidelines recommend in-hospital evaluation with cardiac monitoring and transthoracic echocardiogram (TTE) to assess syncope in patients that are considered high-risk for major adverse cardiovascular events. We sought to identify variables associated with performing TTE in patients presenting with syncope. Methods: We abstracted demographic and clinical data from all patients evaluated for syncope at the [...]