Case Presentation: We are presenting a case of a 71-year-old male patient with a history of hypertension, non-insulin dependent type 2 diabetes mellitus (DM) well controlled on metformin, and non-invasive high grade urothelial bladder cancer diagnosed in 2014 treated with transurethral resection of the prostate and intravesicular mitomycin. In 2016, his bladder cancer has progressed [...]

Case Presentation: A 70 year old male with metastatic malignant melanoma on immunotherapy with nivolumab and ipilimumab was sent to the hospital by his oncologist for abdominal pain and elevated liver enzymes.  His labs were notable for AST 275, ALT 1138, alkaline phosphatase of 394 and total bilirubin of 3.94. This patient had no known [...]

Case Presentation: A 78 year old man with recurrent metastatic adenosquamous lung carcinoma (recently initiated pembrolizumab), CAD s/p CABG, HTN, DM2, and HLD, presented with 2 weeks of fatigue, myalgias, anorexia, and weakness acutely worsening in the prior 2 days. He had no fever, chills, chest pain, dyspnea, orthopnea, palpitations, or lower extremity edema. ED [...]

Case Presentation: 90-year-old female presented with generalized weakness, nausea, vomiting, and diarrhea of 3 days duration. She also reported anorexia but denied any fever, chills, abdominal pain, chest pain, shortness of breath and cough. Vital signs were unremarkable. Physical exam was remarkable for dry oral mucous membranes, the presence of bilateral nephrostomy tubes and costovertebral [...]

Case Presentation: Our patient was a 58 year old male with a history of metastatic melanoma on nivolumab and ipilimumab who was directly admitted from clinic to the medicine service for increased lethargy and flu-like symptoms. The patient described a one week history of fevers/chills, headache, muscle ache, and malaise; as well as nausea, vomiting, [...]

Case Presentation: The patient is a 38-year-old Caucasian female who was diagnosed with Stage IIIb malignant melanoma. The excision of the left scapular lesion and axillary dissection was performed. Baseline 18F-FDG PET scan showed no evidence of metastatic disease. After the 5th cycle of Nivolumab treatment, the patient developed 38 ºC fever and grade 2 [...]

Case Presentation: This case describes a 63-year-old male who was recently diagnosed with renal cell carcinoma with metastasis to the lungs confirmed with a biopsy showing diffuse PAX-8 positivity on an immunohistochemical staining panel favoring renal origin. He was started on Nivolumab/Ipilimumab however was hospitalized in the intensive care unit for septic shock due to [...]

Case Presentation: A 66-year-old female with metastatic small cell lung cancer involving brain, liver, and bones was admitted via ED with generalized weakness, mild confusion, and decreased oral intake for 3 days. She was initiated on immunotherapy with immune checkpoint inhibitors, ipilimumab (human cytotoxic T-lymphocyte antigen 4 (CTLA-4)-blocking antibody) and nivolumab (a programmed death receptor-1 [...]

Case Presentation: A 76-year-old female with a history of hypertension, BMI 48 kg/m2, hypothyroidism, and metastatic melanoma presented with a 2-week history of progressive myalgia, weakness, and dyspnea 3 weeks after the first infusion of nivolumab and relatlimab.In July 2019, she was diagnosed with stage IIB (cT4a, cN0, cM0) melanoma of the left leg (4.2 [...]

Case Presentation: A 77 year old man with stage IIIC mucosal melanoma, hypothyroidism, HTN and COPD presents from an outside hospital with two months of rapidly progressive altered mental status. He was diagnosed with melanoma of the oral palate, left parotid gland and neck one year ago, and underwent two cycles of ipilimumab (ipi) and [...]