Background: The clinical evaluation of febrile neonates ≤ 60 days has been extensively debated in the age of doing less invasive testing to yield the same clinical outcomes with fewer complications. Rates of serious bacterial infections (SBI) in this population have been reported to be between 8.5% and 12%, and up to 20% in neonates [...]

Background: Neonatal herpes simplex virus (HSV) infections are one of the most clinically challenging infections of the newborn period because of the often subtle presentation and devastating consequences of a missed diagnosis. The availability of HSV polymerase chain reaction (PCR) testing has led to widespread use of both HSV testing and empiric therapy but guidelines [...]

Background: Urinary tract infections (UTIs) are a common bacterial infection in infants, with potentially serious consequences. Even though urinalysis (UA) is a commonly used screening test for UTI, there is a lack of consensus on its accuracy in well-appearing febrile infants below 28 days old. This study aims to evaluate the accuracy of UA, both [...]

Background: Infants ≤ 60 days of age with a urinary tract infection (UTI) represent a challenging population without clear guidelines for diagnostic evaluation or antibiotic therapy. UTI represents a significant percentage of serious bacterial infection in this age group and is a common management dilemma for pediatricians. Our study examined patterns of UTI management in [...]