Background: Glucagon-like peptide-1 (GLP-1) agonists are increasingly prescribed for obesity and type 2 diabetes, demonstrating efficacy in weight loss and glycemic control [1-3]. Beyond metabolic effects, these medications show protective effects against renal disease progression and reduce major adverse cardiovascular events [4]. GLP-1 agonists influence body composition through effects on both fat mass and fat-free [...]

Background: Novel coronavirus (COVID-19) has resulted in over 1 million deaths globally(1). Prognostic tools to identify high risk patients are crucial to guide resource allocation efforts(2). We aimed at developing a risk assessment tool for patients with COVID-19 based on the risk factors with most significant effect on hospital admission and in-hospital mortality. Methods: We [...]

Background: Over 6-months after the end of the Covid-19 Public Health Emergency, U.S. hospitals are still experiencing unprecedented levels of sustained stress with national hospital occupancy remaining 10 percentage points higher than before the pandemic. The demand for hospitalization is likely to increase over the next decade as the U.S. population ages, which will place [...]

Background: Despite having the highest health care spending, the US continues to have rates of maternal mortality over three times greater than similarly high-income countries. Generally, deaths occur in the days immediately following birth, and typically occur in hospital intensive care units (ICUs). As ICU utilization is often employed to identify indication of severe maternal [...]

Background: Mitochondrial disease (MD) refers to a group of clinically heterogeneous disorders that result from dysfunctional oxidative phosphorylation and subsequent cellular incapability to meet energy demands. Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), myoclonus, epilepsy, ataxia with ragged red fibers (MERRFs), chronic progressive ophthalmoplegia, Kearns–Sayre syndrome, and sensory ataxia neuropathy dysarthria ophthalmoplegia are among [...]

Background: Ventricular tachycardia (VT) is the most common cause of wide complex tachycardia and a potentially fatal cardiac rhythm disorder. Ventricular arrhythmias, including VT, cause approximately 25% of sudden cardiac deaths. Some studies have proposed a dose-response relationship between VT burden and risk of mortality; however, these studies may have been limited by the inclusion [...]

Background: A priority of bedside electrocardiographic (ECG) monitoring is identification of ventricular tachycardia (VT), a lethal arrhythmia associated with morbidity and mortality. However, up to 87% of VT alarms could be false. In addition, little is known about the rate of mortality associated with VT. We assessed the rate of 30-day in-hospital mortality associated with [...]

Background: It has been unclear about prevalence and in-hospital mortality of severe hypophosphatemia among hospitalized medical patients. Predictors for in-hospital mortality have not yet been determined in terms those may include serum nadir phosphate level, hemolytic complication from hypophosphatemia, or baseline disease as a cause of hypophosphatemia . Methods: A retrospective cohort study was conducted [...]

Background: Atrial fibrillation (AF) is condition associated with increased risk of death in multiple populations (1). The association between AF and COVID-19 infection has started to be explored, but largely in specific geographic locations and/or within the context of the hospitalization (2). By understanding the relationship between COVID-19 and AF, providers may be better supported [...]

Background: Glucagon-like peptide-1 (GLP-1) agonists are increasingly prescribed for obesity and type 2 diabetes, demonstrating efficacy in weight loss and glycemic control [1-3]. Beyond metabolic effects, these medications show protective effects against renal disease progression and reduce major adverse cardiovascular events [4]. GLP-1 agonists influence body composition through effects on both fat mass and fat-free [...]