Case Presentation: We present a 41-year-old female with a past medical history of hypertension and ESRD status post deceased donor kidney transplant in 2018, on treatment with tacrolimus and Mycophenolate Mofetil.She presented to an urgent care 4 days prior, where she tested positive for symptomatic COVID-19 infection and was prescribed a 5-day course of nirmatrelvir-ritonavir. [...]

Background: Contemporary treatment for COVID-19 includes the use of SARS-2-CoV direct-acting antivirals (DAAs). An FDA assessment in the Medicare and Veterans Affairs population has suggested that individual agents in this class have significant differences in drug-drug interaction (DDI) potential based on their pharmacokinetic profiles; however, the clinical impact is not well established. We sought to [...]

Background: More frequently, clinicians encounter patients with mild-to-moderate COVID-19 (defined as patients whose oxygen saturation remains above 94% on room air)1 in the hospital setting.2 These patients may have acquired COVID-19 in the hospital or have tested positive for COVID-19 while presenting to the hospital for another condition.3 Many of these patients are high risk [...]