Case Presentation: Hemophagocytic lymphohystiocytosis (HLH) is a rare cause of pancytopenia. Patients with sickle cell disease can present with pancytopenia and recognition of (HLH) in patients with sickle cell disease may be a lifesaving diagnosis.Case presentation:A 39-year-old female with past medical history of sickle cell anemia and moyamoya disease was admitted with sickle cell vaso-occlusive [...]

Case Presentation: A 12-year-old Caucasian male with no significant medical history presented with a 6-day history of bilateral leg pain following a soccer game. As an avid soccer player, he had experienced similar episodes over the past three years, managed previously as “growing pains” with NSAIDs and acetaminophen. However, this presentation raised concern for an [...]

Background: Sickle cell disease (SCD) affects about 100,000 people in the US. The disease causes significant mortality, morbidity and frequent hospitalizations secondary to primary manifestations of the disease and its complications. We conducted a retrospective, single institution study in adult patients (pts), ≥ 18 years with SCD to assess factors associated with health care utilization [...]

Background: Approximately 10% adults with Sickle Cell disease (SCD) has Pulmonary hypertension (PHTN). There are several etiologies like hypoxia driven and microvascular obstruction contributing to PHTN. However, the in-hospital outcomes of PHTN on SCD has not been well studied. Methods: We queried 2018 National Inpatient Sample (NIS) database to identify SCD and different types of [...]

Background: Sickle cell disease (SCD) and its vasoocclusive sequela are significant causes of morbidity and mortality as well as acute care utilization throughout the United States, with an estimated 92,880 hospital admissions totaling $759 million in aggregate annual costs in 2014. There is a need within health care systems to identify strategies for achieving higher [...]

Background: Nationally, a minority of patients with complex medical and psychosocial needs consume a disproportionate amount of healthcare. In the U.S. in 2015, the top 1% of the population accounted for 23% of all healthcare expenditures and cost ten times more per year than the average patient. No one disease accounts for a large percentage, [...]

Background: Care of hospitalized patients with Sickle Cell Disease (SCD) presents unique challenges due to variability in care, the interplay of acute and chronic pain, and the complex social determinants of health among patients with SCD. Despite comprising only a small percentage of admissions at our academic medical center, admissions for acute SCD-related illnesses have [...]

Background: A vaso-occlusive episode (VOE) is a common complication of sickle cell disease (SCD). The most common presentation of VOE is pain that, if undertreated, can lead to life-threatening complications. Nearly all persons with SCD will have a VOE, however, data show that patients frequently receive inadequate analgesia when being treated for acute pain related [...]

Case Presentation: We describe a 54-year-old male with past medical history of sickle cell disease, who initially presented with worsening dyspnea over the span of two weeks. He had no history of fevers, chills, chest pain, or lower extremity edema, but he did report a chronic dry cough for approximately one year. The patient’s oxygenation [...]

Case Presentation: We present a case of 26-year-old female presented with acute ischemic stroke. She presented with altered mental status from Rehabilitation center. She has history of sickle cell and recurrent strokes in the past. Extensive prior work up for recurrent strokes was done and she was thought to have Moyamoya disease. Before this presentation, [...]