Case Presentation: A 72-year-old male with a history of ischemic cardiomyopathy, infectious endocarditis, subarachnoid hemorrhage, and esophageal cancer presented with symptoms of fever, altered mental status, bilateral lower extremity weakness, spasms and pain. Of note, the patient was on nivolumab, undergoing targeted radiation therapy for esophageal cancer; and vancomycin and cefepime for infectious endocarditis. The [...]

Case Presentation: A 70-year-old man treated with Nivolumab for metastatic melanoma, presented with mild nausea and vomiting for a few days. He denied a change in urine output or appearance of urine, flank pain, or difficulty urinating. Creatinine on admission was 8.9 mg/dl (baseline 0.8mg/dl). Urinalysis revealed mild proteinuria, 21-50 WBCs/hpf. Spot protein/creatinine ratio was [...]

Case Presentation: An elderly man was diagnosed with clear cell renal cell carcinoma in 1987, and treated with left nephrectomy, though developed multi-organ metastatic disease in 2015. After he did not tolerate initial treatment with sunitinib, he received 15 cycles of NKTR-214 and nivolumab as part of a phase I/II study. Three months after his [...]