Case Presentation: A 44-year-old man with multiple myeloma and cardiac amyloidosis on chemotherapy, and atrial fibrillation on apixaban, presented with three days of worsening shortness of breath and edema. He was admitted to the emergency room observation unit for treatment of a mild heart failure exacerbation. He was noted on admission to have rapidly developed [...]

Background: The diagnostic process is fraught with diagnostic uncertainty. Typically, discussions about diagnostic uncertainty occur upon admission and during rounds, which are increasingly conducted virtually during the COVID-19 pandemic. Furthermore, key dimensions in the diagnostic process (history taking, physical examination, interpretation of diagnostic tests) are affected by breakdowns in communication between patients and clinicians, physical [...]