Background: Penicillin discovered in 1928 by Sir Alexander Fleming, beginning of the antibiotic revolution. Penicillin as helped increase average life Span in USA from 47 years to 78.8 years. Beta lactam account to about 40% of total antibiotic use every year. 10% of patients in U.S. report penicillin allergy, but 9 out of 10 patients [...]

Background: Ceftriaxone or cefotaxime has been the drug of choice to treat spontaneous bacterial peritonitis (SBP) for many years, but little is known about microbiology, resistance rate to cephalosporines, and clinical outcomes over the last few decades. Our study aimed to describe the clinical and microbiological characteristics of culture-positive SBP at University of Kentucky Hospital. [...]

Case Presentation: A 54 year-old man with a history of opioid use disorder, housing insecurity and hypoplastic myelodysplastic syndrome presented with one month of shortness of breath, productive cough, fever, and chills. He also endorsed a twenty pound weight loss over the course of three months. He had presented to an outside hospital three weeks [...]

Case Presentation: A 68-year-old male with a history of heavy cigarette smoking and COPD presented with a six-month-long hacking cough with sputum production, night sweats, weight loss, and malaise. He was treated with multiple courses of azithromycin for community-acquired pneumonia without improvement. He had a history of asbestos exposure as a shipyard worker. He did [...]