Case Presentation: A 76-year-old male with metastatic renal cell carcinoma presented to the hospital due to multiple syncopal episodes. The patient was prescribed pembrolizumab by infusion every 3 weeks (last dose was a week and a half prior). His presenting vitals were significant for a heart rate of 30 beats per minute and systolic blood [...]

Case Presentation: Immunotherapy is an emerging therapeutic option in the field of oncology. Dermatological toxicities are the most prevalent immune-related adverse events associated with immunotherapy. Herein, we report a case of a 60-year-old male who developed localized bullous pemphigoid after nearly a year of treatment with a PD-1 inhibitor, nivolumab, for metastatic renal cell carcinoma. [...]

Case Presentation: Our patient is a 66-year-old man, a former 100-pack year smoker, with a history of hypertension, gastroesophageal reflux, emphysema, who was diagnosed in September of 2019 with stage IV squamous cell lung cancer (PD-L1 0%). He was initiated on concurrent radiation with carboplatin and nab-paclitaxel. He had a partial response to this treatment [...]

Case Presentation: An 85 y/o man with non-small cell lung cancer and osseous metastases on pembrolizumab presented with 5 months of progressive weakness, intermittent nausea with non-bloody emesis, and decreased appetite with 20 lb. unintentional weight loss. Interval cancer surveillance with PET CT obtained 1 week prior showed a decrease in disease burden suggestive of [...]

Case Presentation: A 55 yo male with past medical history significant for metastatic renal cell carcinoma with no clinical evidence of residual disease on maintenance pembrolizumab, alcohol abuse, hypertension, and chronic obstructive pulmonary disease, presented after a fall with unknown loss of consciousness and head trauma. His condition progressed to acute encephalopathy with sepsis, multiorgan [...]

Case Presentation: 44 year-old Caucasian woman presented with shortness of breath and weakness. She had a history of stage IIIC malignant melanoma (BRAF Wild Type) of right face. She underwent excision of the lesion a year prior to presentation and immunotherapy with ICI (intravenous Nivolumab 240mg every 2 weeks) was initiated. After 10 cycles of [...]

Case Presentation: We present a case of a 64-year-old woman with metastatic neuroendocrine pancreatic carcinoma with abrupt left facial and oculomotor cranial nerve palsy as well spastic tetraplegia after one dose of Ipilimumab/Nivolumab. She had a history of sudden onset diplopia, fever and ground-level fall a few hours after her initial dose of immunotherapy. Initial [...]

Case Presentation: An 81-year-old woman with a pertinent history of primary hypothyroidism and lung adenocarcinoma, treated with durvalumab, was admitted to the hospital in shock after being found lethargic, hypotensive, and hypoxic at home.Prior to admission, she developed weakness, fatigue, anorexia, vomiting, and diarrhea. She had recently been hospitalized with presumed septic shock attributed to [...]

Case Presentation: A 68-year-old male presented to the hospital with declining mental status. His chronic medical conditions included stage IV renal cell carcinoma on nivolumab maintenance therapy, type II diabetes mellitus, chronic kidney disease, hypothyroidism on levothyroxine 150 mcg, and long-term opioid therapy for malignancy pain. He had a one-week duration of upper abdominal pain [...]

Case Presentation: An 80-year-old male with a history of atrial fibrillation post-ablation on apixaban, COPD, hypertension, and Stage IIIC malignant melanoma post-immunotherapy with nivolumab complicated by non-resolving pneumonitis presented with worsening dyspnea and tachycardia. In the ED, he was found to have atrial flutter with rapid ventricular response (RVR), elevated high-sensitivity troponin, and brain natriuretic [...]