Background: Point-of-care ultrasound (POCUS) of the inferior vena cava (IVC) can help to noninvasively predict the effectiveness of treatment for volume-sensitive conditions, such as acute heart failure and shock. Recently POCUS-IVC has also been used to iteratively tailor fluid treatment to patient-specific targets. In real-world clinical settings, such iterative assessments are necessarily obtained by multiple [...]

Background: Point-of-care ultrasound (POCUS) of the inferior vena cava (IVC) can help to noninvasively predict the effectiveness of treatment for volume-sensitive conditions, such as acute heart failure and shock. Recently POCUS-IVC has also been used to iteratively tailor fluid treatment to patient-specific targets. In real-world clinical settings, such iterative assessments are necessarily obtained by multiple [...]

Case Presentation: A 47-year-old male with history of hypertension presented to urgent care with one day of vomiting and bloody diarrhea. Onset of symptoms occurred 30 minutes after consuming raw juice he made at home from a lauki bottle gourd. At urgent care he was pale, ill-appearing, and hypotensive with a blood pressure of 80/36 [...]

Background: In 2011, sepsis accounted for more than $20 billion (5.2%) of total US hospital costs.  The CDC estimates that hospitalizations for sepsis or septicemia increased from 621,000 to 1,141,000 in 2000 and 2008 respectively.  Severe sepsis has an in-hospital mortality rate of 28.6-37.7%, and those who survive may face a difficult recovery including long-term [...]

Background: Hospitalized COIVD-19 patients are complex and heterogenous with regards to socio-demographics and comorbidities and many patients are at heightened risk for adverse clinical outcome. Early risk stratification enables clinical decision making for appropriateness and timeliness of interventions. Since the pandemic began, more than 100 models to forecast prognosis for hospitalized patients with COVID 19 [...]

Background: Asthma is one of the most common chronic medical conditions affecting around 300 million people worldwide. It is a disorder of the airways characterized by recurrent symptoms of airway obstruction and inflammation. Invasive mechanical ventilation for patients admitted to the hospital with asthma is challenging with higher complications and higher rates of patient-ventilator asynchrony, [...]

Case Presentation: A 49-year-old male with primary sclerosing cholangitis and newly diagnosed locally advanced cholangiocarcinoma was initiated on 5-Fluorouracil (FU) based chemotherapy (FOLFOX) as an outpatient (Figure 1). Within one day of receiving FOLFOX, the patient presented to the ED with acute, intermittent chest pain radiating to his left arm and shortness of breath. Vital [...]

Background: Patients with cardiac arrest, either with a shockable or non-shockable rhythm, are at high risk of death and neurological impairment. Hypoxic-anoxic brain injury is a major cause of morbidity and mortality in these patients. (1) International Liaison Committee on Resuscitation (ILCOR) recommends moderate therapeutic hypothermia (32°C to 36°C) for patients who achieve return of [...]

Background: Sepsis and septic shock, critical health concerns in the U.S., demonstrate varied mortality rates across different racial groups. This study examines the impact of race on mortality and complications in septic shock, providing insights into healthcare disparities. Methods: Using data from the National Inpatient Sample database (2016-2020), this retrospective analysis included 2,789,890 patients with [...]

Background: Sepsis, severe sepsis, and septic shock combined, are estimated to affect between 650,000 and 750,000 Americans annually, and has an associated mortality rate between 20 to 50%.  Early identification of patients with sepsis is critical, as treatment delays are associated with significant increases in mortality. The electronic health record (EHR) contains near-real-time physiologic parameters, [...]