Background: Cardiovascular disease remains the leading cause of death in the United States. Approximately every 40 seconds, an American will have a myocardial infarction. The aim of this project is to assess the progress of the prevention and management of myocardial infarction by using the National Inpatient Sample (NIS) data. Methods: This is a retrospective [...]

Background: The healthcare system needs tools that can predict which patients are at risk of deterioration, before adverse outcomes such as cardiac arrest or even death occur. Many of these patients will show signs of significant physiological deterioration in the 24 hours prior to ICU transfer or cardiac arrest [1-4]. Different scores have been developed [...]

Background: Persons with opioid use disorders (OUD) represent a disproportionately high percentage of hospitalized patients, have greater lengths of stay and readmissions, can incur higher costs, and are at greater risk of drug-related death immediately post-discharge. Further, despite the availability of effective medications for OUD, patients often are not offered treatment during the inpatient encounter. [...]

Background: Mitochondrial disease (MD) refers to a group of clinically heterogeneous disorders that result from dysfunctional oxidative phosphorylation and subsequent cellular incapability to meet energy demands. Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), myoclonus, epilepsy, ataxia with ragged red fibers (MERRFs), chronic progressive ophthalmoplegia, Kearns–Sayre syndrome, and sensory ataxia neuropathy dysarthria ophthalmoplegia are among [...]

Background: Postmyocardial Infarction Syndrome (PMIS), also called Dressler syndrome or Post-pericardiotomy Syndrome, refers to a heterogeneous group of autoimmune-mediated conditions of pericardial, epicardial and myocardial inflammation following myocardial infarction. Generally considered to be rare in the reperfusion era, the features and risk factors of PMIS are less well characterized in the contemporary era. This study [...]

Background: In patients hospitalized with heart failure (HF) exacerbations, physicians routinely supplement potassium to maintain levels ≥4.0 mEq/L. The evidence basis for this practice is relatively weak. We aimed to evaluate the association between serum potassium levels and outcomes in patients hospitalized with HF. Methods: We identified patients admitted with acute HF exacerbations to hospitals [...]

Background: In the United States, 32 million people have a documented penicillin allergy and up to 20% of hospitalized patients’ records describe a penicillin allergy (PcnA). Less than 10% of patients with reported penicillin allergy have true clinically relevant PcnA when objectively tested through rigorous skin testing (1-3). Clinicians subsequently avoid appropriate penicillin or penicillin [...]

Background: Trust has long been considered an important element in the doctor-patient relationship, and historically physicians have been considered one of the most trusted professions in the US. However, recent data suggests that patient trust in the healthcare system has eroded. One hypothesized cause of this loss of trust is the breakdown of the doctor-patient [...]

Background: Many hospitals have focused on discharging patients before noon as a goal to improve throughput and decrease length of stay. However, those patients who can be discharged early in the day may actually represent a loss and not a win for the system, as they could have potentially been discharged the evening before. Methods: [...]

Background: It has been recently shown that patients admitted at night and during the weekend have worse mortality outcomes. The impact of those variables on other important outcomes such as length of stay (LOS) and readmission is less clear. We sought to analyze this relationship in a large cohort of inpatients. Methods: We performed a [...]