Background: Stroke is the leading cause of mortality worldwide. However, available treatment options are limited due to the narrow treatment time window and reperfusion injury after revascularization. New treatment modalities to overcome these challenges are in need. Chlorpromazine and promethazine (C+P) have been utilized for cerebral edema, central high fever with restlessness, and delirium [1, [...]

Background: Stroke is one of the most common causes of adult mortality. With changes in lifestyle, the increase in risk factors is leading to an increase in the number of cases. Mean platelet volume (MPV) is associated with an increase in platelet size and hence increased production of pro-inflammatory cytokines and increased expression of platelet [...]

Background: Statin use has been shown to be beneficial in secondary stroke prevention. However, the optimal LDL level that should be achieved is still uncertain. Since there is a dearth of information, it is unclear if statins are useful in patients with stroke with baseline LDL ≤70 mg/dl in terms of morbidity and mortality outcomes. [...]

Background: Approximately one-third of patients with acute ischemic stroke (AIS) develop hyperglycemia regardless of pre-existing history of diabetes [1]. Hyperglycemia is associated with increased risk of hemorrhagic transformation and can be considered as a predictor of poor functional outcome after intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) [2]. Additionally, risk of death, hemorrhagic complications, and [...]

Background: Patent Foramen Ovale (PFO) is a common abnormality that affects between 25% and 34% of the general population. For most people, it is a benign finding; however, in some, the PFO can be wider, allowing a paradoxical embolus to transit from the venous to the arterial circulation, which is associated with cryptogenic stroke, migraine, [...]

Background: Ischemic stroke (IS) is a cerebrovascular disease with high incidence and mortality. White matter repair plays an important role in the long-term recovery of neurological function after cerebral ischemia. Neuroprotective microglial responses can promote white matter repair and protect ischemic brain tissue. The aim of this study was to investigate whether hypoxic post-conditioning (HPC) [...]

Case Presentation: This is an otherwise healthy 28-year-old female who presented with sudden, atraumatic left lower extremity paresis. With the same onset, she noted left-sided paresthesia and left upper extremity weakness. She additionally had a history of two episodes of transient, unilateral blurred vision. On admission, her examination revealed intact cranial nerves. Strength was intact [...]

Case Presentation: A 77 y/o male with a past medical history of metastatic renal cell carcinoma to lungs, hypertension, and chronic renal disease presented to the hospital for an elective CT-guided needle biopsy of a left upper lobe lung nodule. Post biopsy he developed an acute onset of right-sided weakness, difficulty speaking, and altered mental [...]

Case Presentation: A 48-year-old female was referred to Neuromuscular Medicine (NMM) for left-sided spasticity. She has a past medical history of low back pain, opioid addiction, and constipation. The patient in early 2022 had a right cerebral artery (RCA) aneurysm and underwent surgical clipping. She experienced a right hemispheric ischemic stroke postoperatively, which caused left [...]

Case Presentation: Contradictory to stroke prevention by left atrial appendage occlusion (LAAO) device, we present a case of a gentleman who suffered an air embolic stroke in the right fronto-temporal region during the procedure. 66-year-old male with a history of atrial fibrillation was undergoing LAAO device procedure. Air was noticed in his left ventricle which [...]