Background: Anticoagulants are among the highest-risk medications in hospitalized patients. Studies have demonstrated that a majority of in-hospital anticoagulant adverse drug events are not only preventable, but are the result of excessive dosing. This is especially true for warfarin dosing, which is complicated by a lack of consensus among validated initial dosing nomograms. As part [...]

Case Presentation: 69 year old woman with atrial fibrillation on warfarin and unspecified connective tissue disease on prednisone presented to the emergency department (ED) with worsening, painful bilateral lower extremity skin lesions. She noted a mildly painful, non-healing left leg wound 3 months prior to presentation; then a 2nd similar lesion appeared on her right [...]

Case Presentation: 68-year-old obese woman with history of recurrent urinary tract infections (UTI) presented with weakness and abdominal pain after failed outpatient treatment for UTI with Nitrofurantoin. During hospitalization, she was noted to be dyspneic and hypoxemic. Patient denied chest pain or discomfort, paroxysmal nocturnal dyspnea, orthopnea, dizziness, syncope or pre-syncope, slurred speech or focal [...]