Background: Treatment of complicated urinary tract infections (cUTI), including acute pyelonephritis (AP) due to multi-drug resistant (MDR) Gram-negative uropathogens (e.g., extended-spectrum ß-lactamase (ESBL)-producing and fluoroquinolone-resistant strains) is associated with poor outcomes and increase costs of care. In the setting of limited alternative oral options, patients with cUTI/AP are commonly hospitalized to receive intravenous (IV) antibiotic [...]

Case Presentation: A 27-year-old Chinese-American woman presented to the ED for sore throat, flank pain, dysuria, and generalized weakness for 1 week. The symptoms began after returning on a domestic flight. She initially denied any medical history or substance use to multiple providers and insisted her symptoms were due to infrequent bathroom use during the [...]

Background: Tebipenem pivoxil hydrobromide (TBP-PI-HBr) is an orally bioavailable prodrug that is rapidly converted in plasma to the carbapenem, tebipenem. Tebipenem has in vitro activity against select multidrug-resistant Gram-negative pathogens, including fluoroquinolone-resistant and extended-spectrum ß-lactamase (ESBL)-producing Enterobacterales. TBP-PI-HBr is being developed in the United States as the first oral carbapenem for treatment of cUTI and [...]

Case Presentation: MERS is a radiological-clinical diagnosis with distinct MRI findings and neurological symptoms often associated with an infectious process. Clinical symptoms can include headache, vision changes, delirium, abnormal speech, and seizures. Brain MRI classically demonstrates symmetric lesions in the splenium of the corpus callosum with restricted diffusion. MERS is generally self-limiting and often occurs [...]

Case Presentation: A 43-year-old woman with uncontrolled type II diabetes mellitus, hypertension, CKD stage 3, and prior history of pyelonephritis complicated by E. coli bacteremia, presented with vomiting, anorexia, fever, chills, and mild abdominal discomfort. Exam was notable for normal vital signs, mild diffuse abdominal tenderness, and no costovertebral angle tenderness. Laboratory studies showed a [...]

Case Presentation: A 56-year-old female with history of spastic quadriplegia secondary to multiple sclerosis, neurogenic bladder with a long-term indwelling suprapubic catheter presented with septic shock. ​ Labs revealed leukocytosis and lactic acidosis. A contrast enhanced computed tomography of abdomen and pelvis revealed a multiloculated large right renal abscess with staghorn calculus extending into the [...]

Case Presentation: A 61-year-old female with history notable for Crohn´s disease in remission presents with dysphagia associated with an unintentional 16kg weight loss over six weeks. Review of symptoms is notable for chronic diarrhea which stopped 3 days prior to admission and acute dysuria and polyuria. She is afebrile and hemodynamically stable. Initial laboratory studies [...]