Case Presentation: A 74-year-old female with a history of restless leg syndrome, hypertension, GERD, presented with worsening fatigue, shortness of breath, and anasarca over the last 6 months. Labs revealed anemia (hemoglobin, 8.0 g/dL), thrombocytopenia (platelet count, 46K/μL), reticulocyte count 11.4%, undetectable serum haptoglobin, serum LDH >2700 U/L, ferritin 1223 ng/mL, negative direct Coomb’s test, [...]

Case Presentation: An 82-year-old female presented to the emergency department with a hemoglobin of 5.2 g/dL and complaints of nausea, fatigue, and progressive weakness over the past 2 months. She denied any episode of overt bleeding; no hemoptysis, hematochezia, hematuria, or bloody vaginal discharge. She also denied trauma or any recent falls. The patient’s physical [...]

Case Presentation: A 64-year-old male with a medical history of psoriatic arthritis on etanercept, coronary artery disease, adrenal insufficiency and alcohol use disorder who presented to the hospital with complaints of weakness, fatigue, night sweat, and transient slurring of speech. Physical examination was normal. Laboratory investigation showed Hemoglobin of 10, Platelets 150, WBC 6, CRP [...]

Case Presentation: A 54-year-old Hispanic woman presented with 5 days of subjective fevers, jaundice, nausea, vomiting, and right-sided abdominal pain. On presentation, she was febrile with borderline hypotension and tachycardia, abdominal tenderness, and laboratory values notable for leukopenia and transaminitis with direct hyperbilirubinemia. The patient received vancomycin, cefepime, metronizadole, and intravenous fluids per sepsis protocol. She was intubated [...]

Case Presentation: An 83-year-old man visiting from rural Mexico, presented with one-month-old diffuse, painful, multinodular subcutaneous lesions with a pruritic rash on the left leg. A week prior to admission, the patient reported new inguinal and upper extremity lesions and a violaceous, pruritic, non-painful, maculopapular rash at the waistband with progression to the upper arms. [...]

Case Presentation: We present a case series of three patients who developed secondary B-cell acute lymphoblastic leukemia (B-ALL) after multiple myeloma (MM) treatment. Case 1: A 71-year-old male with a four-year history of standard-risk kappa MM presented with weakness, fever, cough, and pancytopenia. His MM had initially been treated with six cycles of lenalidomide (R), [...]

Case Presentation: Mycosis fungoides (MF) is a rare cutaneous T-cell lymphoma that progresses from patch-stage dermatitis to tumor-stage lesions. While primarily a dermatologic malignancy, MF can involve systemic organs or transform into more aggressive malignancies. Composite lymphomas (CL), characterized by the coexistence of two distinct lymphomas in one patient, are rare and diagnostically challenging. We [...]

Case Presentation: An 81-year-old woman was referred with a 1-month history of subacute progressive bilateral leg edema and a 1-week history of pain and inflammation in both lower legs. She had no history of fever or weight loss. Physical examination revealed pitting bilateral edema with tenderness. No heart murmurs or jugular venous distention were noted. [...]

Case Presentation: A 73-year-old woman with a history of coronary artery disease and remote cervical cancer presented to the hospital with a two-month history of progressive leg weakness and confusion. Over the course of six weeks, symptoms progressed to flaccid paralysis and loss of sensation in both legs. Magnetic resonance imaging (MRI) demonstrated enhancing hemorrhagic [...]

Case Presentation: 52-year-old male presented with six-week history of unintentional weight loss, decreased appetite and non-radiating dull suprapubic pain. Review of systems was notable for constipation, polyuria, polydipsia, nausea, and left leg swelling. No family history of cancer or blood dyscrasias. Physical examination revealed blood pressure- 194/114 mmHg, heart rate -105, distended abdomen with hypoactive [...]