Case Presentation: A 73-year-old woman with past medical history of metastatic endometrial adenocarcinoma previously treated with Pembrolizumab (stopped 4 months prior) presented with six weeks of persistent fatigue, myalgias, nausea, and vomiting. On presentation, she was noted to be hypotensive with labs notable for hyponatremia and hypomagnesemia. She appeared lethargic with dry mucous membranes and [...]

Case Presentation: We are presenting a case of a 71-year-old male patient with a history of hypertension, non-insulin dependent type 2 diabetes mellitus (DM) well controlled on metformin, and non-invasive high grade urothelial bladder cancer diagnosed in 2014 treated with transurethral resection of the prostate and intravesicular mitomycin. In 2016, his bladder cancer has progressed [...]

Case Presentation: A 71-year-old African American male presented to the emergency department due to chest pain, fevers and shortness of breath with associated dry cough. The symptoms progressively worsened since onset one month prior to admission. He was HIV negative with a history of Stage IV (T2a N2 M1a) lung adenocarcinoma diagnosed one year ago [...]

Case Presentation: A 63-year-old female with no prior oncologic history was found to have a right breast mass via ultrasound guided biopsy. Pathology showed invasive poorly differentiated metaplastic carcinoma triple negative breast cancer. She was started on neoadjuvant chemotherapy, including Keytruda (pembrolizumab) every 3 weeks. During therapy, she developed Grade 1 fatigue and anemia. Baseline [...]

Case Presentation: An 85 y/o man with non-small cell lung cancer and osseous metastases on pembrolizumab presented with 5 months of progressive weakness, intermittent nausea with non-bloody emesis, and decreased appetite with 20 lb. unintentional weight loss. Interval cancer surveillance with PET CT obtained 1 week prior showed a decrease in disease burden suggestive of [...]

Case Presentation: A 78-year-old female with a history of uterine carcinosarcoma diagnosed two years ago presented to the ED with a primary complaint of orbital swelling, blurry vision, and diplopia OS. One week prior, she received her 5th and 1st cycle of Pembrolizumab and Zometa infusion, respectively for her uterine carcinosarcoma. Three days status post, [...]

Case Presentation: A 55 yo male with past medical history significant for metastatic renal cell carcinoma with no clinical evidence of residual disease on maintenance pembrolizumab, alcohol abuse, hypertension, and chronic obstructive pulmonary disease, presented after a fall with unknown loss of consciousness and head trauma. His condition progressed to acute encephalopathy with sepsis, multiorgan [...]

Case Presentation: 75 year-old male with nasal NK/T non-Hodgkin lymphoma (stage II B) in second relapse on salvage Pembrolizumab (checkpoint inhibitor) presented with fatigue, skin irritation and arthralgias. Initial blood work showed hyponatremia. Patient had a low plasma osmolality and was euvolemic on exam. Urine sodium was 96MeQ/L. Patient had a low serum cortisol which [...]

Case Presentation: A 59 year old man with stage IV lung adenocarcinoma of the right lower lobe with metastases to the ribs and thoracic vertebra presented with shortness of breath, diplopia, and dysphagia. Six weeks prior to presentation he was treated with one cycle of carboplatin, pemetrexed, and pembrolizumab along with palliative radiation therapy to [...]

Case Presentation: A 68-year man presented to the hospital due to 2 weeks of acute abdominal pain with nausea, vomiting, diarrhea and the inability to tolerate his jejunostomy tube feeds, resulting in 20lbs of weight loss. Past medical history includes Stage 4 gastric adenocarcinoma, coronary artery disease, and hypertension. After diagnosis of gastric cancer 1 [...]