Background: Acute heart failure (AHF) exacerbations are a leading cause of hospitalization in the United States. Despite the frequency of AHF hospitalizations, there are inadequate data or practice guidelines on how quickly diuresis should be achieved. Methods: We conducted a pooled cohort study using data from three acute heart failure trials (DOSE, ROSE, and ATHENA-HF). [...]

Background: Acute heart failure (AHF) exacerbations are a leading cause of hospitalization in the United States. Despite the frequency of AHF hospitalizations, there are inadequate data or practice guidelines on how quickly diuresis should be achieved. Methods: We conducted a pooled cohort study using data from three acute heart failure trials (DOSE, ROSE, and ATHENA-HF). [...]

Background: Data on epidemiology of cardiovascular diseases (CVD) in patients with autosomal dominant polycystic kidney disease (ADPKD) are limited. In this study, we assess the prevalence of CVD in patients with ADPKD and evaluate the association between these two entities. Methods: Using the national inpatient sample database, we identified 71,531 hospitalizations among adults aged ≥18 [...]

Background: Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are commonly-used antihypertensives which, despite renoprotective properties, can contribute to acute kidney injury (AKI)(1). Iodinated contrast media may also precipitate AKI, namely contrast-induced nephropathy (CIN), which has been associated with adverse patient outcomes(1–3). ACE inhibitors and ARBs are often held in the setting of iodinated [...]

Background: Acute kidney injury (AKI) following cardiac surgery occurs in 30% of cases with 1% requiring dialysis resulting in significant morbidity and mortality.  HMG-CoA Reductase Inhibitors (“statins”) have been postulated to be of benefit in this population, however results from existing clinical studies have been inconsistent. Since there is abundance of evidence showing that short-term [...]

Background: Since the start of the coronavirus disease 2019 (COVID-19) pandemic, millions have succumbed to the infection worldwide. The virus is most well-known for its devastating pulmonary and cardiovascular manifestations, but acute kidney injury (AKI) has been frequent as well (reported incidence ranging from 0.5% to 56.9%), and has been repeatedly observed to be associated [...]

Background: Transjugular intrahepatic portosystemic shunt (TIPS) creation is a commonly utilized procedure used for patients with chronic liver disease and resistant portal hypertension. Previous studies have explored the trends and short-term outcomes in TIPS procedures. This study aims to further compare short-term in-hospital outcomes of patients with chronic kidney disease when undergoing TIPS. Methods: This [...]

Background: The novel coronavirus disease 2019 (COVID-19) has demonstrated a range of presentations and outcomes affecting multiple organ systems. Acute kidney injury (AKI) associated with hospitalized patients with COVID-19 and related outcomes vary widely according to early reports. This study aimed to determine the prevalence of AKI, AKI in the setting of chronic kidney disease [...]

Background: Researchers across the globe have continued their effort in identifying important risk factors for severe COVID-19 infection. Patient demographics including age, race, gender, and certain chronic medical conditions including cardiovascular disease, diabetes, hypertension, and heart failure have been identified as the important risk factors for severity. To simply the risk stratification process, the CHA2DS2-VASc [...]

Background: Kidney dysfunction is a risk factor for several health problems, such as ischemic heart disease, stroke, peripheral artery disease, chronic kidney disease, and gout. This study aims to analyze the global disease burden caused by kidney dysfunction at the national, regional, and territorial levels. Methods: As part of our ecological investigation, we used the [...]