Background: Syphilis cases in the United States increased by 28.6% between 2020 and 2021. San Francisco was the highest-risk county for early syphilis in 2017, and between 2017 and 2021, syphilis diagnoses further increased by 12%, with a 200% increase in syphilis cases among women and a 333% increase in congenital syphilis cases compared to [...]

Case Presentation: A 41-year-old male presented to the ER two days after sudden-onset vision loss in his right eye while driving which he described as a “round black spot the size of a large clock.” This prompted him to stop his car and get out, after which he felt off-balance for 10 minutes. The vision [...]

Case Presentation: An otherwise healthy 31 years old Brazilian male presented to the hospital with two months history of constitutional symptoms, diffuse pruritic rash on torso and extremities, and diffuse lymphadenopathy. He lived with his wife and daughter, and most recent travel to Brazil was three months ago. His father has diabetes and mother died [...]

Case Presentation: A 44-year man with history notable for illicit drug use (amphetamine, cocaine), poorly controlled HIV (CD4 count 387, HIV quantitative PCR with a viral load of 188,000) and anaphylaxis with penicillin use presented with a 1-day history of sore throat along with a 1-month history of a warm, diffuse, symmetric, non-pruritic, non-vesicular, maculopapular [...]

Case Presentation: A 45 year-old man with no past medical history presented with recurrent nausea, vomiting, and abdominal pain. He had previously been admitted for nausea and vomiting and was diagnosed with gastritis and discharged home with pantoprazole. It initially improved but he began experiencing postprandial nausea and vomiting again 3-4 weeks ago. His intermittent [...]

Case Presentation: A 40-year-old man presents with painful, progressive bilateral vision loss which began two months prior, and was described as the patient feeling as if he were “looking through a straw”. He noted excruciating eye pain, redness, and tearing. Despite work as a tree trimmer, patient denied known trauma. He endorsed a twenty-pound unintentional [...]

Case Presentation: A 59-year-old male with a history of HIV, HBV, and amphetamine use disorder presented with a three-day history of fever, diffuse abdominal pain, and rectal pain with passage of thick, clear-yellow fluid. The patient engaged in receptive anal intercourse and had a history of injecting methamphetamine per rectum. Patient was septic on admission [...]

Case Presentation: Case Presentations: Five new cases of ocular syphilis were diagnosed and treated at Naval Medical Center Portsmouth between December 2020 and August 2021. Although this manifestation is rare, there has been an increase in rate of occurrence of newly diagnosed syphilis cases every year since 2000, to include preliminary data from the CDC [...]

Case Presentation: There is a trend for increasing frequency of primary and secondary syphilis in developed countries, especially in men who have sex with men. Ocular manifestations of syphilis are rare, occurring in less than one in 1 million persons. Distinctive patterns of syphilitic uveitis include white, focal preretinal opacities, and acute posterior placoid uveitis. [...]

Case Presentation: 56-year-old male with no significant medical history presented to our hospital with progressive monocular vision loss, initially referred by ophthalmology for new diagnosis of uveitis. He initially noticed blurring of vision in his right eye about one month prior to presentation. His ophthalmologist started him on a combination of atropine and Difluprednate eye [...]