Case Presentation: A 74 year old female with a history of atrial fibrillation presented to the emergency room due to a 1 week history of respiratory distress.  She was tachypneic (respiratory rate = 24) and her room air oxygen saturation level was 91 per cent.  Diminished breath sounds in the lower third of her left [...]

Case Presentation: A 21 year old male with no significant past medical or surgical history presented to the hospital with sudden onset of bilateral lower extremity paralysis and paresthesia. He was lifting heavy boxes at work when he felt severe lower back pain that eventually radiated to his legs. The pain was followed by bilateral [...]

Case Presentation: A 20-year-old female, nonsmoker, G1P0 at 25 weeks, presented to the ED with left leg swelling. Ultrasound confirmed a left femoral DVT. CBC and CMP were unremarkable. She started enoxaparin 80mg twice daily and followed with OB/GYN. Her hypercoagulable workup showed a prolonged aPTT and DRVVT, which corrected with mixing, indicating absence of [...]

Case Presentation: A 55-year-old female presented with headaches and intermittent fevers. On initial examination, she had left hand weakness. Laboratory findings revealed leukocytosis; brain MRI demonstrated multiple bilateral cerebral infarcts. Initial workup was concerning for embolic stroke which initiated our search for a cardioembolic source. No significant abnormalities were seen on transthoracic echo (TTE) and [...]

Case Presentation: A 62-year-old male with past medical history of type 2 diabetes mellitus, coronary and peripheral arterial disease, heart failure with reduced ejection fraction, history of peripheral arterial embolism, history of stroke, vascular dementia and hypertension who presented with sudden onset of shortness of breath associated with cough and chest pain for one day. [...]

Case Presentation: A 59-year-old man with a history of a chronic provoked bilateral pulmonary embolism with left lower extremity deep vein thrombosis (DVT), Non-ST-elevation myocardial infarction and hypercholesterolemia presented to the emergency department with acute, severe, constant left calf pain and swelling, exacerbated by standing. He stated that “I think I have another blood clot [...]

Case Presentation: A 65 year-old man with primary antiphospholipid syndrome (APS) was transferred to our hospital for management of refractory thrombocytopenia and thrombosis. His disease was diagnosed by positive lupus anticoagulant, anti-cardiolipin antibody, beta-2-glycoprotein IgM and IgG, and was well controlled with warfarin for years. His worsening APS was precipitated by traumatic subdural hematomas and [...]

Case Presentation: A 94-year-old woman with a history of atrial fibrillation (not on anticoagulation), coronary artery disease, and metastatic lung adenocarcinoma (on Osimertinib) presented following a syncopal episode, which was complicated by a left thigh hematoma. On admission, she was hemodynamically stable, although her bloodwork was concerning for disseminated intravascular coagulation (DIC) including a hemoglobin [...]

Case Presentation: A 34-year-old Caucasian lady with metabolic syndrome and hypertension presented with a sudden onset 10/10 right lower extremity pain associated with numbness and inability to ambulate. Vital signs were stable. On examination, her right lower extremity was pale, cold and pulseless. Her laboratory tests including hypercoagulable workup were normal. A CT aortogram with [...]

Case Presentation: A Caucasian man in his 60s presented to the ED with a 6-week history of extensive bruising, worse in both legs and buttocks, along with shortness of breath on minimal exertion. He stated he had a chronic wound on his right leg (Figure 1). He was not taking any regular medications. Days later [...]