Case Presentation: We present a 41-year-old female with a past medical history of hypertension and ESRD status post deceased donor kidney transplant in 2018, on treatment with tacrolimus and Mycophenolate Mofetil.She presented to an urgent care 4 days prior, where she tested positive for symptomatic COVID-19 infection and was prescribed a 5-day course of nirmatrelvir-ritonavir. [...]

Background: Transcatheter tricuspid valve procedures (TTVP) are used to manage tricuspid regurgitation, however these procedures are less common than other transcatheter valve procedures. Limited literature on TTVP exists, especially with regards to predictors of major outcomes. Atrial fibrillation (afib) is associated with increased mortality, stroke, cardiogenic shock, need for permanent pacemaker, AKI, major bleeding in [...]

Background: Unexpected overnight adverse events are known to correlate with worse outcomes in inpatients.  Unfortunately, the exact occurrence and etiologies of such events have been less known.    Purpose: The aim of our study was to clarify the occurrence, etiologies of unexpected overnight adverse events and also propose the algorithm so that the catastrophic events [...]

Background: Sickle cell disease (SCD) is an autosomal recessive disease resulting in a broad range of functional and structural renal and cardiac alterations. Chronic kidney disease is with associated proteinuria, microalbuminuria and hemoglobinuria. Cardiac complications include diastolic heart disease, dysrhythmia and sudden death. In patients with advancing age, cardio-renal dysfunction can have substantial effects on [...]

Background: Revefenacin (REV), a once-daily, long-acting muscarinic antagonist for nebulized inhalation, was recently approved for maintenance treatment of chronic obstructive pulmonary disease (COPD). We present post hoc efficacy and safety data from three phase 3 trials in patients with moderate to very severe COPD by patient subgroup (<65 y, 65–75 y, >75 y). Methods: This [...]

Background: The healthcare system needs tools that can predict which patients are at risk of deterioration, before adverse outcomes such as cardiac arrest or even death occur. Many of these patients will show signs of significant physiological deterioration in the 24 hours prior to ICU transfer or cardiac arrest [1-4]. Different scores have been developed [...]

Background: Mitochondrial disease (MD) refers to a group of clinically heterogeneous disorders that result from dysfunctional oxidative phosphorylation and subsequent cellular incapability to meet energy demands. Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), myoclonus, epilepsy, ataxia with ragged red fibers (MERRFs), chronic progressive ophthalmoplegia, Kearns–Sayre syndrome, and sensory ataxia neuropathy dysarthria ophthalmoplegia are among [...]

Background: Semaglutide, a Glucagon-like peptide-1 (GLP-1) agonist, has become one of the most prescribed medications as a result of its beneficial cardiovascular profile and beneficial side effect of weight loss. There is a paucity in literature about its adverse effects. We aimed to conduct a meta-analysis of the severe adverse effects (SAE) of Semaglutide using [...]

Background: In the inpatient setting, opioids are the most commonly prescribed medication and the 2nd most frequent cause of adverse drug events (ADE).  Identifying patients at high risk for ADEs related to narcotics is essential.  These ADEs include ileus, altered mental status, and respiratory depression. Obstructive sleep apnea, organ impairment, and other medication use (i.e. [...]

Background: Incident reporting systems are widely utilized to detect adverse events and remain central to many hospital patient safety programs. It is well established that non-physicians file the majority of incident reports, but the barriers to physician reporting are not well understood. Therefore the aims of this study are to understand physicians’ perceived barriers to [...]