Background: In 2020, melanoma exhibited the 5th highest incidence rate of all cancers in the US. While metastatic melanoma constitutes only 4% of new melanoma cases, the 5-year survival rate of metastatic melanoma is 27% [1]. Immune Checkpoint Inhibitors (ICIs) were the first drugs to significantly improve the 5-year survival of late-stage melanoma patients; these [...]

Background: Choroidal melanoma, the most common primary intraocular malignancy in adults, is a dangerous cancer which can lead to blindness. Diagnosed at an average age of 65 & lacking identifiable environmental or genetic factors, melanoma of the eye can affect anyone. Commonly found on routine ophthalmological screening, patients are sent to quaternary hospitals for further [...]

Case Presentation: A 70 year old male with metastatic malignant melanoma on immunotherapy with nivolumab and ipilimumab was sent to the hospital by his oncologist for abdominal pain and elevated liver enzymes.  His labs were notable for AST 275, ALT 1138, alkaline phosphatase of 394 and total bilirubin of 3.94. This patient had no known [...]

Case Presentation: A 69 year old man with stage IV melanoma (with brain, lung, adrenal, and gastric metastases) s/p treatment with three cycles of ipilimumab/nivolumab last 1 week ago presented with 6 days of lightheadedness, nausea, and generalized fatigue. While waiting to see oncologist bystanders witnessed the patient become unconscious with jerking motions of his [...]

Case Presentation: A 44 year-old Hispanic female with a past medical history of hypothyroidism presented from her endocrinologist with a diffuse, maculopapular rash, including the face, hands, wrists, torso, arms and legs. The rash had been intermittent for the past six years, painful, pruritic, and exacerbated by sunlight. She also complained of joint pain and [...]

Case Presentation: 47-year-old male veteran presented with one-month history of intermittent left-sided abdominal pain, vomiting, constipation and melena. Abdominal X-ray revealed small bowel obstruction. CT scan of the abdomen and pelvis with contrast revealed multifocal masses involving proximal to mid-small bowel with small bowel obstruction secondary to the mass at the level of jejunal and [...]

Case Presentation: A 31 yo male bodybuilder with a history (> 10 yrs) of testosterone and aromatase inhibitor (AI) use presented to the ED after a focal seizure. He reported recent difficulty with fine motor function, unintentional weight loss, and growth of multiple painless nodules over the past 3 to 6 months.Physical exam revealed inguinal [...]

Case Presentation: A 36-year-old man presented with a one-month history of fevers, night sweats, low back pain, and an enlarging nodule on his back. Physical exam revealed left axillary adenopathy, diminished breath sounds at bilateral bases, and an irregularly shaped 10 cm pigmented lesion (image 1) on his left posterior hemithorax. Labs were notable for [...]

Case Presentation: A 63 year old female with metastatic melanoma to brain and breast presented to the emergency department with altered mental status. She was disoriented to time and place and unable to follow commands. She had received two doses of immunotherapy with ipilimumab and nivolumab. Her last dose was administered two weeks prior. She [...]

Case Presentation: A 61-year-old male presented with complaint of left arm swelling with left axillary lump, which had been worsening for two months. He reported of having a dark-colored left forearm skin lesion which he reportedly removed by himself 15 years ago without seeking medical care. Computed Tomography of chest revealed too numerous to count [...]