Background: Contemporary treatment for COVID-19 includes the use of SARS-2-CoV direct-acting antivirals (DAAs). An FDA assessment in the Medicare and Veterans Affairs population has suggested that individual agents in this class have significant differences in drug-drug interaction (DDI) potential based on their pharmacokinetic profiles; however, the clinical impact is not well established. We sought to [...]

Background: Identification of pathogens causing community-acquired pneumonia (CAP) in hospitalized patients has improved with the utilization of nasopharyngeal (NP) polymerase chain reaction (PCR). Literature shows that 20-25% of pathogens are identified when using urine antigens, sputum and blood cultures, and can improve up to 70% when adding NP PCR for viruses, Staphylococcus aureus and Streptococcus [...]

Background: Asthma, bronchiolitis, and pneumonia are common pediatric inpatient diagnoses. Viral testing (VT) is not routinely necessary for these diagnoses as it often does not impact management. Our study objectives for each diagnosis are to; 1) describe trends in VT over the last 5 years including seasonal variation (respiratory season- Oct-March versus non-respiratory season- April-Sept), [...]

Case Presentation: A 40-year-old healthy woman, presented with two weeks of cough, nasal congestion, sore throat, intermittent fevers, fatigue, and myalgia but no weakness. She tested positive for the SARS-Cov-2. Physical exam showed no neurologic deficit. Two weeks later, respiratory symptoms were improving but she developed sudden, leg pain, numbness, and weakness. She described it [...]

Case Presentation:  A 41 year-old male with HIV/AIDS (diagnosed three years ago), cutaneous Kaposi Sarcoma (KS), started on combination antiretroviral treatment (cART) three months ago (CD4 270, Viral load (VL) >2000 at the time of initiation of cART), recent VL of 39, who presented with worsening shortness of breath, cough, abdominal pain, abdominal distention and [...]

Case Presentation: A 20-year-old man with a history of type 1 diabetes mellitus presented with five days of sore throat and intermittent fever. Two days prior to presentation, he was evaluated with findings including tachycardia with a heart rate of 124, fever to 38.7 degrees C, and an exam notable for tonsillar & oropharyngeal exudate [...]

Case Presentation: A 14yo girl presented with syncope and 4 days of URI symptoms. She had no past medical or family history. On presentation, she was hypotensive with mildly elevated lactate, troponin, and BNP, and an unremarkable ECG and chest radiograph. Initial echocardiogram showed normal LV function. Cardiac MRI revealed a pericardial effusion and increased [...]

Case Presentation: A 43-year-old male with human immunodeficiency virus (HIV), off antiretroviral therapy (ART) for 5 years presented to an outside hospital in July 2022 with diffuse umbilicated skin lesions. Skin scrapings for the monkeypox virus PCR were positive. No medications were prescribed. Days later, the patient was admitted to a different hospital with worsening [...]

Case Presentation: JD is a 23 yo AA M with no prior PMH presented with fevers, rash, myalgias, chills, nausea and vomiting. The rash began three days prior to admission, began over the palms and spread to the forearms, chest and back. A couple of weeks ago, JD started selling his plasma, prior to that [...]

Case Presentation: A 35 year-old undomiciled male with a history of epilepsy and recurrent aseptic meningitis was brought in to the emergency department after being found unresponsive. Initial vital signs were notable for temperature of 102˚F. He was intubated in the emergency department and a lumbar puncture was done consistent with a bacterial meningitis (WBC [...]