Session Type
Meeting
Search Results for Warfarin
Abstract Number: 143
Hospital Medicine 2018; April 8-11; Orlando, Fla.
Background: Warfarin and other anticoagulants increase the risk of hemorrhagic complications, including upper gastrointestinal hemorrhages (UGIB). Warfarin is commonly used in the management of atrial fibrillation to reduce the risk of ischemic stroke, and frequently resumed following UGIB. However, optimal timing of reinitiation remains unclear. Theory suggests that resuming warfarin immediately after UGIB would lead […]
Abstract Number: 156
Hospital Medicine 2018; April 8-11; Orlando, Fla.
Background: While anticoagulants are the core treatment plan for preventing strokes in patients with atrial fibrillation and managing patients with thromboembolic disease, there is a dichotomy of efficacy and harm with their use. Rapid inpatient reversal protocols are important for patient safety. Four factor prothrombin complex concentrate (4FPCC) is approved for reversal of warfarin-induced coagulopathy. […]
Abstract Number: 157
Hospital Medicine 2018; April 8-11; Orlando, Fla.
Background: Warfarin-associated adverse drug events are dangerous, common, and costly. Anticoagulation safety is a national priority. While multiple tools exist for warfarin management in the outpatient setting, there is a dearth of guidance with regard to inpatient management. This study aims to: 1) describe a health system’s inpatient chronic warfarin quality metrics, defined by International […]
Abstract Number: 159
SHM Converge 2023
Background: Although novel oral anticoagulants (NOAC) have been proven as effective alternatives to warfarin in patients with atrial fibrillation, the effectiveness of NOACs in patients with artificial (bioprosthetic and mechanical) heart valves is not known. This systematic review and meta-analysis evaluates multiple clinical outcomes between warfarin and NOACs in patients with artificial heart valves. Methods: […]
Abstract Number: 173
Hospital Medicine 2018; April 8-11; Orlando, Fla.
Background: Warfarin is commonly used in long-term anticoagulation and has a narrow therapeutic index. Dosing is dependent on intrinsic patient variables including cytochrome P450 2C9 (CYP2C9) and VKORC1 polymorphisms. High protein binding and CYP-dependent clearance mechanisms of NSAIDs also affect warfarin serum levels. This study investigates the observed pharmacologic interaction of concurrent NSAID and warfarin […]
Abstract Number: 213
Hospital Medicine 2019, March 24-27, National Harbor, Md.
Background: Anticoagulants are among the highest-risk medications in hospitalized patients. Studies have demonstrated that a majority of in-hospital anticoagulant adverse drug events are not only preventable, but are the result of excessive dosing. This is especially true for warfarin dosing, which is complicated by a lack of consensus among validated initial dosing nomograms. As part […]
Abstract Number: 508
Hospital Medicine 2017, May 1-4, 2017; Las Vegas, Nev.
Case Presentation: A 68-year-old white male with a history of Factor V Leiden, deep vein thromboses (DVT), pulmonary embolism (PE), atrial fibrillation, and hyperthyroidism on warfarin therapy for 12 years presented to the emergency department (ED) with acutely worsening, bilateral, black, necrotic ulcerations of his lower extremities with associated edema, purpura, and progressive sloughing of […]
Abstract Number: 553
Hospital Medicine 2018; April 8-11; Orlando, Fla.
Case Presentation: A 56-year-old female with a history of a deep vein thrombosis (DVT) during pregnancy and dementia presented with dyspnea and acute hypoxemia. Shortly thereafter, she developed persistent fevers and acute encephalopathy. Initial testing, including lumbar puncture, chest x-ray, multiple blood cultures, urine cultures, respiratory cultures, and RPR were all unremarkable. CT head was […]
Abstract Number: 579
Hospital Medicine 2020, Virtual Competition
Case Presentation: A 74 year old female with history of atrial flutter on warfarin presented to the emergency department with altered mental status and bilateral leg pain. She was found to have a leukocytosis (WBC 14.7), pre-renal azotemia and an elevated INR of 8.2. Exam was notable for bilateral lower extremity ulcers. She was treated […]
Abstract Number: 661
Hospital Medicine 2018; April 8-11; Orlando, Fla.
Case Presentation: A 62-year-old man presented with 5 weeks of progressive right lower extremity ulceration associated with pain, swelling, erythema, fevers, and diaphoresis. Initially, outpatient providers diagnosed patient with cellulitis following minor trauma and complicated by chronic venous stasis. Medical history included poorly-controlled insulin-dependent type 2 diabetes, atrial fibrillation on warfarin, recurrent venous stasis ulcers, […]