Case Presentation: A 47-year-old woman with lupus presented with one week of urinary frequency and dysuria. Over the prior year, she had pelvic pain, night sweats, 20 pounds of unintentional weight loss, and eight episodes of pan-susceptible E. coli urinary tract infections (UTIs), each successfully treated. Her chronic medications were prednisone, hydroxychloroquine, and azathioprine.A computed [...]

Background: Individuals with autoantibodies against melanoma differentiation-associated protein 5 (MDA-5) are reported to have a significant risk of developing rapidly progressive and fatal interstitial lung disease (ILD) in clinically amyopathic dermatomyositis patients (CADM). Previous cohort studies of dermatomyositis patients who have been systematically evaluated for the presence of anti-MDA5 antibodies and associated clinical features and [...]

Case Presentation: A 73-year-old male with history of type 2 diabetes and one-month prior admission for acute renal failure in the setting of stage IV chronic kidney disease presented with symptomatic anemia found to have splenomegaly. A renal biopsy revealed features of membranoproliferative glomerulonephritis and necrotizing crescentic lesions with IgM kappa deposition, suspicious for cryoglobulinemic glomerulonephritis. Immunofixation [...]

Case Presentation: A 68-year-old man with hypertension and osteoarthritis presented with fever, cough, dyspnea, and weight loss for 2 months. Prior to admission, he had received antibiotics for community-acquired pneumonia without improvement. Physical exam showed multiple ulcers at the base and sides of tongue, bilateral palmar erythematous papules with ulceration and scaling, bilateral erythematous plaques [...]

Case Presentation: A 70 year old male with past medical history of chronic kidney disease was admitted with three weeks of progressive right-sided upper and lower extremity weakness, tremors, and slurred speech. He first noticed right upper extremity weakness and tremors three weeks ago when he could not play his guitar and presented to the [...]

Case Presentation: A 57-year-old male patient with a previous history of alcohol use was brought in by his family for progressive myoclonus and confusion. At baseline, this patient performed activities of daily living with ease. He had no history of neurologic disorders, however his mother had been diagnosed with dementia in her 70s. Over the [...]

Case Presentation: A 43-year-old male with a history of diffuse large B-cell lymphoma (DLBCL) in remission for 2 years after chimeric antigen receptor (CAR) T-cell therapy presented to his PCP with headaches and a mild cough. A PCR COVID-19 test was positive, a head CT showed cerebral edema, and MRI had diffuse dural thickening without [...]

Case Presentation: A 40-year-old woman with no prior past medical history presented to the emergency room with several weeks of dysphagia, rash on her face, hands, chest, accompanied by fatigue, malaise, followed by progressively worsening shortness of breath. Over 8 weeks, she also developed a rash over her dorsal hands and upper chest wall, associated [...]

Case Presentation: A 24-year-old African-American woman presented with nausea, flank pain, and hematuria recurring over several months. Review of symptoms and past medical history were negative. She was a current smoker. Family history was noncontributory. Physical exam was significant for bilateral flank pain. Laboratory testing, serology, and kidney biopsy led to the diagnosis of rapidly [...]

Case Presentation: 70-year-old female with ILD and bullous pemphigoid (BP) on mycophenolate mofetil and prednisone initially presented to emergency room for hematuria and chills, where she was found to have elevated creatinine of 1.25 mg/dL (baseline creatinine 0.4 mg/dL) and prescribed a course of ciprofloxacin for hemorrhagic cystitis. She was admitted three days later due [...]