Background: Hematopoietic stem cell transplantation (HSCT) remains the only definitive treatment for many benign and malignant hematologic disorders. Despite advances in transplant medicine, HSCT still carries a significant risk of serious complications, including idiopathic pneumonia syndrome (IPS). IPS is characterized by diffuse alveolar injury that is not due to infection or fluid overload. IPS affects [...]

Background: Hepatic artery pseudoaneurysm (HAP) is a rare entity, potentially life threatening and associated with high mortality. The aim of this study was to evaluate Mayo Clinic enterprise’s clinical experience with HAP occurrence, clinical features and outcome in the last 20 years, and to compare our results with what the literature. Methods: This retrospective analysis [...]

Background: Data is emerging on the efficacy of fecal microbial transplantation (FMT) for recurrent clostridium difficile infection (CDI) management with success rates of 80-90% in general population. Immunocompromised patients continue to be excluded from randomized trials involving FMT due to concerns related to its safety and efficacy. Current guidelines recommend caution with FMT in immunocompromised [...]

Background: Hematopoietic stem cell transplantation (HSCT) can be a life-saving and curative therapy in hematological malignancies. Pre-transplant evaluation for HSCT is a multidisciplinary process that can be complicated, time-consuming, and expensive for patients to navigate. The process requires coordination between several medical subspecialties including pulmonary, cardiology, and mental health, in addition to social workers and [...]

Background: Despite advances in pharmacologic care for side effects of Hematopoietic stem cell transplant, patients often suffer from long hospitalizations, multiple side effects including fatigue, insomnia, nausea, anxiety, and poor sleep. Non-pharmacologic treatments for side effects of therapy are attractive adjuncts due to a low side effect profile. Purpose: To develop, implement and evaluate a [...]

Background: Myelofibrosis is a chronic myeloproliferative neoplasm characterized by progressive bone marrow fibrosis and extramedullary hematopoiesis leading to splenomegaly. Progressive splenomegaly is common in advanced myelofibrosis, and spleen volume is a predictor of survival. The oral selective small-molecule JAK 1/2 inhibitor ruxolitinib is used for symptomatic management of intermediate-2 and high-risk myelofibrosis, and leads to [...]

Case Presentation: A 56-year-old man presented with one day of high fevers to 104°F, myalgias, and non-productive cough. His past medical history is significant for polycystic liver disease leading to liver transplant, and metastatic neuroendocrine tumor managed with intravenous somatostatin. Two weeks prior to admission, he began a taper of his immunosuppressive medication. On the [...]

Background: Successful hospitalist co-management programs address provider knowledge base as well as ongoing faculty skill development and education (1). With a growing liver transplant program, our institution has seen increased patient volume on the hospitalist liver service. Hospitalists and hepatologists co-manage this expanding population of high acuity patients with complex pathologies. In the past year, [...]

Background: Patients who have undergone hematopoietic stem cell transplantation (HSCT) are at a higher risk of infection compared to their healthy counterparts. This retrospective chart review aimed to elucidate the incidence and etiology of skin infections in HSCT patients and understand the relationship between these infections and graft-versus host disease (GVHD), neutropenia, and transplant type. [...]

Case Presentation: A 29-year-old otherwise healthy man presented to the emergency room with five weeks of progressively worsening pruritus and fatigue. The patient denied recent ingestion of herbal supplements, and reported lifetime abstinence from alcohol use. Physical exam revealed jaundice and scleral icterus. No ascites or hepatomegaly were noted on initial exam. Admission labs revealed [...]