Background: Among patients undergoing cardiac surgery on cardiopulmonary bypass (CPB), post-operative complications are common, occurring in up to 67% of patients, and significantly impact long-term outcomes. We conducted a Phase 2 clinical trial of RBT-1, a pharmacologic preconditioning drug, to assess cytoprotective biomarkers and clinical outcomes. Herein, we report our final results. Methods: This randomized, [...]

Background: Transcatheter tricuspid valve procedures (TTVP) are used to manage tricuspid regurgitation, however these procedures are less common than other transcatheter valve procedures. Limited literature on TTVP exists, especially with regards to predictors of major outcomes. Atrial fibrillation (afib) is associated with increased mortality, stroke, cardiogenic shock, need for permanent pacemaker, AKI, major bleeding in [...]

Background: Several case reports and case series have found that transcatheter mitral valve procedures (TMVP) improve hemodynamics and reduce symptoms in patients with mitral valve disease and concomitant hypertrophic obstructive cardiomyopathy (HOCM).(1-6) There is a lack of evidence regarding the outcomes of patients that undergo TMVP with HOCM, however several studies have evaluated the outcomes [...]

Case Presentation: A 57-year-old female with a medical history of uncontrolled diabetes with a hemoglobin A1C of 14, hypertension, and a previous right-sided stroke presented to the emergency department with a four-day history of nausea, vomiting, watery diarrhea, fever and chills. On presentation, the patient was hemodynamic stable with no fevers. Physical examination revealed no [...]

Case Presentation: Heyde syndrome is a rare multisystem disorder characterized by the triad of aortic stenosis (AS), gastrointestinal bleeding, and acquired von Willebrand syndrome (AVWS). The pathophysiology of AVWS in Heyde syndrome is thought to be due to the increased circulatory shear forces resulting from AS, leading to cleavage of large VWF multimers and loss [...]

Case Presentation: A sixty-six-year-old male with a history of Monoclonal Gammopathy of Undetermined Significance (MGUS), Atrial Fibrillation, and Rheumatic Heart Disease requiring aortic and mitral valvuloplasty, was on warfarin with an INR goal of 3.5-4 due to multiple hypercoagulable factors and recurrent Transient Ischemic Attacks (TIAs) at INR 2.5-3.5. Post prostate cancer radiation, he developed [...]

Case Presentation: A 73-year-old woman with past medical history of hypertension was discovered unresponsive at home, prompting initiation of CPR during transportation to the Emergency Department, resulting in the restoration of spontaneous circulation (ROSC). A chest x-ray indicated the presence of left-sided tension pneumothorax, necessitating the placement of a chest tube. Initial electrocardiogram (EKG) findings [...]

Case Presentation: A 61-year-old male with past medical history of HIV on HAART with undetectable viral load and bicuspid aortic valve (BAV) presented to the hospital with fevers, abdominal pain and diarrhea for three days found to have sepsis with leukocytosis of 13.7×10^3/uL and fever of 39°C, elevated trop of 168ng/L without acute ischemic changes [...]