Background: Individuals with autoantibodies against melanoma differentiation-associated protein 5 (MDA-5) are reported to have a significant risk of developing rapidly progressive and fatal interstitial lung disease (ILD) in clinically amyopathic dermatomyositis patients (CADM). Previous cohort studies of dermatomyositis patients who have been systematically evaluated for the presence of anti-MDA5 antibodies and associated clinical features and [...]

Case Presentation: A 50-year-old male with history of gastric lap band, obstructive sleep apnea, hypertension, and type 2 diabetes presented with two months of worsening shortness of breath. He denied cough, fever, myalgias, diarrhea, loss of sense of taste or smell, or pleuritic chest pain. He had no history of asthma, COPD, or tobacco use. [...]

Case Presentation: A 68-year-old man with hypertension and osteoarthritis presented with fever, cough, dyspnea, and weight loss for 2 months. Prior to admission, he had received antibiotics for community-acquired pneumonia without improvement. Physical exam showed multiple ulcers at the base and sides of tongue, bilateral palmar erythematous papules with ulceration and scaling, bilateral erythematous plaques [...]

Case Presentation: A 40-year-old woman with no prior past medical history presented to the emergency room with several weeks of dysphagia, rash on her face, hands, chest, accompanied by fatigue, malaise, followed by progressively worsening shortness of breath. Over 8 weeks, she also developed a rash over her dorsal hands and upper chest wall, associated [...]

Case Presentation: 64-year-old female with a past medical history of cerebral palsy presented with recurrent fever. One week earlier, she had been hospitalized for sialadenitis and pneumonia and completed a 10 day course of antibiotics. Family reported recurrent fevers (Tm 102F) after discharge with associated mucosal ulcerations and chronic intermittent joint pain. She did not [...]