Background: Unexpected overnight adverse events are known to correlate with worse outcomes in inpatients.  Unfortunately, the exact occurrence and etiologies of such events have been less known.    Purpose: The aim of our study was to clarify the occurrence, etiologies of unexpected overnight adverse events and also propose the algorithm so that the catastrophic events [...]

Background: Revefenacin (REV), a once-daily, long-acting muscarinic antagonist for nebulized inhalation, was recently approved for maintenance treatment of chronic obstructive pulmonary disease (COPD). We present post hoc efficacy and safety data from three phase 3 trials in patients with moderate to very severe COPD by patient subgroup (<65 y, 65–75 y, >75 y). Methods: This [...]

Background: Incident reporting systems are widely utilized to detect adverse events and remain central to many hospital patient safety programs. It is well established that non-physicians file the majority of incident reports, but the barriers to physician reporting are not well understood. Therefore the aims of this study are to understand physicians’ perceived barriers to [...]

Background: Diagnostic error is commonly defined as a missed or delayed diagnosis and has been described as among the most important patient safety hazards. Diagnostic errors also account for the largest category of medical malpractice high severity claims and total payouts. Despite a large literature on the incidence of inpatient adverse events, no systematic review [...]

Background: Falls are associated with significant morbidity and increased healthcare expenses for hospitalized patients. There are hundreds of thousands of inpatient falls every year. There are multiple validated scores to guide the need of imaging for patients presenting to ED after, but no such score exists for hospitalized patients who suffer a fall event. This [...]

Background: There is evidence that physicians consider a variety of “non-medical” factors (e.g. lack of social support, barriers to access) in hospital admission decision-making out of concern for patient safety, and that patients are hospitalized even in the absence of a level of medical acuity warranting admission. The rationale underlying this decision may overvalue the [...]

Background: Perioperative management of anticoagulant in mechanical valve patients is challenging, Current recommendations focus on management in patients undergoing elective surgery, while the data in patients hospitalized for emergency/urgency non-cardiac surgery is limited. We aimed to identify thromboembolic and bleeding events after anticoagulant interruption in patients with mechanical heart valves hospitalized for emergency/urgent non-cardiac surgery. [...]

Background: Adverse events (AEs) occur in 19-28% of hospitalized patients in the 30 days after discharge [1,2]. Though new or worsening symptoms (NWS) reported by patients are often an early indicator of post-discharge AEs, they are not systematically captured in electronic health record (EHR) documentation or via patient portals. Higher fidelity capture of patient-reported NWS [...]

Background: An estimated 68,000 Americans died of opioid-related overdoses between March 2017-2018. In Monroe County NY heroin/fentanyl deaths are up 200% from 2015- 2017. Guidelines recommending naloxone co-prescription for high-risk patients on opioid pain medications have been issued. The inpatient setting provides unique opportunities for identifying patients at risk for opioid adverse events (OAE) and [...]

Background: Adverse events (AE) are common during care transitions (19-28%) in patients with multiple chronic conditions (MCC) and often lead to unanticipated healthcare resource utilization after discharge. While early indicators of these AEs include new and worsening symptoms, systematic monitoring of patient-reported symptoms is lacking. The 21st Century Cures Act mandates the healthcare industry to [...]