Session Type
Meeting
Search Results for CALCITONIN
Abstract Number: 114
Hospital Medicine 2018; April 8-11; Orlando, Fla.
Background: Procalcitonin (PCT) is a precursor peptide to calcitonin produced by the thyroid parafollicular cells, and the intestinal and lung neuroendocrine cells. PCT is a proinflammatoy marker specific to bacterial infections, and was initially used clinically to guide antibiotic therapy in lower respiratory tract infections. PCT has seen its role expanded to aid with initiation, […]
Abstract Number: 121
Hospital Medicine 2018; April 8-11; Orlando, Fla.
Background: With standard diagnostic methods, the etiologic pathogen of community acquired pneumonia (CAP) is detected in ≤ 50% hospitalized CAP patients. In our previous studies using a diagnostic “bundle”, we were able to detect etiologic pathogens in ≥ 70 % of the patients. Our bundle consisted of a nasopharyngeal swab for Biofire film array, that […]
Abstract Number: 192
SHM Converge 2023
Background: Febrile infants under 60 days-old undergo extensive evaluation for infection. Recent AAP guidelines recommend evaluation of the procalcitonin (PCT) level in the work-up of febrile infants 8-60 days-old to aid in predicting bacterial infection (BI) due to its high specificity; however, the sensitivity of PCT is relatively low. Recent literature has identified the Procalcitonin-To-Albumin […]
Abstract Number: 205
SHM Converge 2023
Background: Due to their widespread availability, inflammatory markers are used with increasing frequency, often concurrently, without adding any diagnostic or clinical benefit1,2. While unnecessary labs do not offer any additional benefit, they can be a significant source of physical and emotional distress to patients and their families3-5. In an era that emphasizes high-value, low-cost medical […]
Abstract Number: 229
Hospital Medicine 2020, Virtual Competition
Background: Identification of pathogens causing community-acquired pneumonia (CAP) in hospitalized patients has improved with the utilization of nasopharyngeal (NP) polymerase chain reaction (PCR). Literature shows that 20-25% of pathogens are identified when using urine antigens, sputum and blood cultures, and can improve up to 70% when adding NP PCR for viruses, Staphylococcus aureus and Streptococcus […]
Abstract Number: 281
Hospital Medicine 2017, May 1-4, 2017; Las Vegas, Nev.
Background: Inappropriate antibiotic use is associated with bacterial resistance, adverse events, and an increased risk of Clostridium difficileinfection. However, providers often prescribe antibiotics for viral respiratory infections and treat infections such as bacterial pneumonia for unnecessarily prolonged durations. Serum procalcitonin (PCT)-guided treatment is known to safely reduce antibiotic use and duration of treatment in pneumonia. […]
Abstract Number: 315
Hospital Medicine 2020, Virtual Competition
Background: Procalcitonin (PCT) testing has been shown in randomized trials to decrease antibiotic exposure and be a reliable predictor of clinical response to antibiotics in lower respiratory tract infection (LRTI) and sepsis. Although studied to guide antibiotic discontinuation in LRTI and sepsis, optimal strategies for introducing PCT into “real-world” clinical use are unknown. Our study […]
Abstract Number: 340
Hospital Medicine 2020, Virtual Competition
Background: The utility of procalcitonin (PCT) in pediatrics is debated. Proposed diseases in which PCT elevation is thought to be suggestive of a bacterial process include meningitis, urinary tract infection, pneumonia, neonatal fever, and sepsis of unknown source. However, elevated PCT is non-specific for bacterial infection and the strength of the test is generally felt […]
Abstract Number: 342
Hospital Medicine 2018; April 8-11; Orlando, Fla.
Background: Blood stream infection is associated with high mortality and morbidity. Blood cultures are considered the gold standard for diagnosing bacteremia in sepsis patients. However, blood culture results may take at least 12 to 24 hours for a positive result and may even be complicated by contamination. Procalcitonin (PCT) a biomarker for bacterial infection is […]
Abstract Number: 362
Hospital Medicine 2018; April 8-11; Orlando, Fla.
Background: Procalcitonin (PCT) is a biomarker that correlates with the presence of bacterial infection in certain clinical scenarios; it has increasingly accepted indications for antibiotic stewardship. Most sources suggest that antibiotics should be considered for patients with suspected infection and PCT values ≥ 0.25-0.5 ng/ml; conversely, clinicians should consider withholding antibiotics for patients with PCT […]