Background: Olfactory neuroblastoma (ONB), first described in 1924 by Berger et al., is a rare neoplasm that represents nearly 3% of malignant sinonasal neoplasms. It arises from the olfactory epithelium and tends to invaders local structures and metastasizes to various body organs. Given its diverse ad controversial management strategies, this review investigates the clinical and [...]

Background: Tumor necrosis factor-α (TNF-α) plays a role in the pathogenesis of and serves as a biomarker for obstructive sleep apnea (OSA) [1]. Moreover, patients with juvenile idiopathic arthritis (JIA) had a numerically elevated risk of OSA [2-4]. Given TNF-α inhibitors have been widely used to treat JIA, the aim of the present study was [...]

Background: The tumor microenvironment and its interaction with the tumor are indicative of disease progression but has not been clinically applied due to the lack of objective assessment criteria. Proximity associated effects of the tumor to its microenvironment which can explain the long-term behavior of tumor remains to be developed. In this work, we utilized [...]

Background: Cancer screening guidelines based on age, biological sex, and degree of risk are intended to diagnose malignancies early and in the outpatient setting. Despite these efforts, malignancies are often diagnosed while patients are admitted to the hospital. These diagnoses are made either incidentally or after the onset of a clinical condition that necessitates an [...]

Background: Many cancer centers use the hospitalist model in the inpatient setting (1) since hospitalists provide high quality, cost efficient care (2). Our 678-bed quaternary hospital uses oncology hospitalist teams to care for all inpatients with solid tumor malignancies with medical oncology and palliative care consulting as needed. Internal medicine residents and advanced practice fellows [...]

Background: Tumor lysis syndrome (TLS) is a major life-threatening oncological emergency where accelerated damage of rapidly proliferating tumor cells results in critical metabolic derangements including hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia potentially leading to acute kidney injury (AKI) and multi-organ failure. TLS has been well documented in hematologic malignancies but is extremely rare in solid neoplasms, [...]

Case Presentation: 47 year old female with a past medical history of hypertension presented to the emergency room with two days of right upper quadrant pain and a fever to 102F. For several months prior, she complained of bloating, intermittent diarrhea and diffuse abdominal pain that now localized. Her social history was positive for recent [...]

Case Presentation: A previously healthy five-year-old boy presented with forehead swelling in the setting of a recent sinus infection. His initial symptoms were fever and nasal congestion for which he was prescribed a 10-day course of cefdinir, completed three days prior to admission. After finishing the antibiotic, he developed unsteady gait, photophobia, headache, vomiting, and [...]

Case Presentation: A 2-year-old girl with a past medical history of hypertension and anterior mediastinal mass of unclear etiology presents to the ED with acute bruising. 2 months prior, she was admitted to PICU for fever and lethargy, AKI, hyperuricemia and electrolyte abnormalities concerning for tumor lysis syndrome (TLS), and was found to have a [...]

Case Presentation: A 67 year old female with no past medical history presented to our emergency department for new onset shortness of breath, chest pain, and palpitations for 90 minutes. Of note, she reported 8 pound weight gain, generalized fatigue, and abdominal distension for several months prior to presentation. Physical exam revealed a heart rate [...]