Background: Alcohol use disorder (AUD) Is present in 10% of adults and its prevalence is increasing. When patients with AUD are admitted to the hospital, half develop alcohol withdrawal syndrome (AWS), which can cause delirium, hallucinations, seizures, and even mortality if not treated appropriately. A fixed-dose phenobarbital strategy may be superior to the standard of [...]

Background: The diagnosis of sepsis is often associated with high rates of morbidity and mortality. When it occurs in patients with Heart failure (HF), those rates increase dramatically. This study focuses on the differences in the outcomes in septic patients with Heart Failure with preserved Ejection Fraction (HFpEF) versus patients with Heart Failure with reduced [...]

Background: As of 2020, a reported 2.7 million people in the United States have opioid use disorder (OUD). Hospitalizations related to opioid use have risen dramatically over the last two decades. Inpatients with substance use disorders are at increased risk of leaving the hospital prior to treatment completion which can further lead to poor health [...]

Background: Central venous lines (CVL), including temporary dialysis catheters, are often required in the inpatient setting. While CVLs are frequently placed in radiology suites or intensive care units (ICU), many institutions allow placement on medical-surgical wards by Hospitalist Bedside Procedure Services (BPS). The BPS at our institution began to perform CVL placement at the patient [...]

Background: Ventricular tachycardia (VT) is the most common cause of wide complex tachycardia and a potentially fatal cardiac rhythm disorder. Ventricular arrhythmias, including VT, cause approximately 25% of sudden cardiac deaths. Some studies have proposed a dose-response relationship between VT burden and risk of mortality; however, these studies may have been limited by the inclusion [...]

Background: The coronavirus disease 2019 (COVID-19) pandemic has had a profound impact on global health, economies, and society, further increasing strain on public healthcare, while exacerbating psychosocial stressors. Multiple single-center and regional studies have shown an overall increase in national rates of firearm injury-related emergency department (ED) visits (FIRE) during the COVID-19 pandemic. This study [...]

Background: Patients who are hospitalized for a prolonged period are at risk of developing various complications, includingfeeding intolerance resulting from reduced gastrointestinal motility. Prucalopride is one of the drugs used for thetreatment of constipation, and it exerts its effects by increasing intestinal motility through the activation of the 5-HT4receptor.However, no previous study demonstrated whether prucalopride [...]

Background: Semaglutide, a Glucagon-like peptide-1 (GLP-1) agonist, has become one of the most prescribed medications as a result of its beneficial cardiovascular profile and beneficial side effect of weight loss. There is a paucity in literature about its adverse effects. We aimed to conduct a meta-analysis of the severe adverse effects (SAE) of Semaglutide using [...]

Background: Despite their elevated baseline risks for infection and thrombosis, hospitalized medical patients with active malignancy commonly receive multi-lumen peripherally inserted central catheters (PICCs). We sought to assess the relationship between number of catheter lumens and risk of PICC-related complications among patients with active malignancy. Methods: Trained abstractors collected patient level information, including number of [...]

Background: Contemporary treatment for COVID-19 includes the use of SARS-2-CoV direct-acting antivirals (DAAs). An FDA assessment in the Medicare and Veterans Affairs population has suggested that individual agents in this class have significant differences in drug-drug interaction (DDI) potential based on their pharmacokinetic profiles; however, the clinical impact is not well established. We sought to [...]