Case Presentation: Hemophagocytic lymphohystiocytosis (HLH) is a rare cause of pancytopenia. Patients with sickle cell disease can present with pancytopenia and recognition of (HLH) in patients with sickle cell disease may be a lifesaving diagnosis.Case presentation:A 39-year-old female with past medical history of sickle cell anemia and moyamoya disease was admitted with sickle cell vaso-occlusive [...]

Case Presentation: This is a 4-year-old previously healthy girl, fully immunized with the exception of COVID-19 immunizations, who was hospitalized after presenting with fevers and fatigue for one week followed by gross hematuria. At the outset of her fevers, she tested negative for COVID-19 using a home antigen test. 4 days prior to admission, she [...]

Background: Anemia is a risk factor for cognitive impairment as a result of the reduced delivery of oxygen to the brain from low hemoglobin (Hb) levels. In ambulatory patients even mild anemia (Hb < 12g/dL) has been associated with reductions in patients’ cognitive function. However, in hospitalized patients it is standard of care to maintain [...]

Background: In hospitalized patients with anemia, the AABB recommends that transfusion of red blood cells occur when a patient’s hemoglobin (Hb) drops below a restrictive transfusion threshold, either at 7 or 8g/dL1. These transfusion guidelines are the result of a growing body of clinical trial evidence showing that transfusion at lower or restrictive Hb thresholds [...]

Background: The 2016 and 2023 AABB international red blood cell (RBC) transfusion guidelines recommend, in addition to restrictive transfusion practices, that clinicians also consider the patient’s overall clinical context when making transfusion decisions (1). However, there is little empiric data on which specific clinical factors, other than Hb, should inform transfusion decisions in hospitalized patients [...]

Background: In hospitalized patients with anemia the AABB recommends that transfusion of red blood cells occur when a patient’s hemoglobin (Hb) drops below a restrictive transfusion threshold, either at 7 or 8g/dL. These recommendations are the result of a growing body of clinical trial evidence showing that transfusion at estrictive Hb thresholds is safe, compared [...]

Background: The World Health Organization defines anemia in females as a hemoglobin (Hb)

Background: Mental fatigability is a measure of an individual’s susceptibility to increased mental fatigue resulting from engaging in physical and/or mental activities. Mental fatigability is important in hospitalized patients because it is has been shown to be associated with reduced physical activity levels, and reduced activity directly contributes to hospital associated disability and reduced functional [...]

Background: Anemia is an acute and/or chronic condition with a range of underlying etiologies present in an estimated 40-70% of hospitalized patients. While comprehensive diagnostic and treatment algorithms for anemia exist, they are rarely used by hospitalist clinicians in the inpatient setting. This is because these algorithms were derived in ambulatory patients where acute anemia [...]

Background: Anemia is a risk factor for cognitive impairment as a result of reduced delivery of oxygen to the brain from low hemoglobin (Hb) levels. In ambulatory patients, mild anemia (Hb 10-12g/dL) has been associated with reductions in patients’ cognitive function [1–3]. In hospitalized patients it is standard of care to maintain Hb levels far [...]